Fyfe made his debut in Fremantle's 39-point win over the Richmond Tigers in the annual Len Hall ANZAC Day game at Subiaco Oval in 2010.
[6] He collected 23 possessions, four clearances, five tackles and seven marks and played on senior Sydney player Ryan O'Keefe for most of the game.
[7] Fyfe continued to improve and had a sensational second season in the AFL, finishing a close second to Matthew Pavlich in the Doig Medal.
[8] His form led him to be considered as a potential All-Australian team selection and gained comparisons to past champion James Hird.
Fyfe made a strong start to the 2012 AFL Season with a best-on-ground performance against Geelong in their Round 1 match at Patersons Stadium, recording 30 disposals and 2 goals in the 4-point win over the Cats.
[11] Fyfe began dealing with a shoulder injury during April, and attempted to play through it, but was forced out and underwent surgery in May after dislocating it at training.
[13] Despite playing only nine games in the home and away season – two of which were compromised because of his shoulder, Fyfe still polled the second-most Brownlow Medal votes (14) at Fremantle.
[14] Fyfe continued to improve throughout the 2013 AFL Season, increasing his average disposals from the previous two years (25.9) and winning his first Doig Medal, beating out David Mundy.
[15] Fyfe had a hand in leading Fremantle to a 16-1-5 win–loss record, helping them finish third on the ladder, and reaching their first ever AFL Grand Final in club history, but despite having an equal game-high 28 disposals in the match, the Dockers were defeated by Hawthorn by 15 points, ending the club's best season in their 19-year history just short of their first premiership success.
[18] Fyfe started the 2014 AFL Season strongly, but was controversially suspended for two weeks in Round 2 for a bump on Gold Coast player Michael Rischitelli.
[20] Fyfe continued his strong form for the remainder of the season, increasing his average disposal count from 25.9 to 27.0 a game, recording a career-high goals (24), and was now being considered one of the elite midfielders in the league.
Fyfe carried his strong form into the 2015 AFL Season, recording 31 disposals, 1 goal, and 7 inside-fifties in Fremantle's Round 1 win over Port Adelaide.
In February 2017, Fyfe was announced as Fremantle's captain[35] and he returned from his injury during the 2017 JLT Community Series against the West Coast Eagles, he recorded 22 disposals in the 55-point loss.
[38] Fyfe was in career-best form at the start of the 2018 AFL season, playing a match-winning hand in a number of the club's early wins.
[40] Fyfe suffered a hamstring injury in Fremantle's Round 15 clash against the Brisbane Lions, hobbling off in the first quarter, and resulting in him spending six weeks on the sidelines.
[43] After a good start to the 2020 season, which was impacted by the COVID-19 pandemic, Fyfe suffered a minor hamstring injury in Round 4 against Gold Coast.
[47] Fyfe played almost half of the 2021 AFL season before being side lined for three games after injuring his shoulder in Fremantle's Round 12 clash against the Western Bulldogs.
Round 17 saw Fyfe play his 200th game, he was arguably best on ground collecting 31 disposals and kicking a goal in Fremantle's 62-point victory over Hawthorn.
[52] Fyfe was among Fremantle's best in round 17 during the 41 point win over St Kilda at Marvel Stadium, kicking an equal game-high 3 goals and collecting 21 disposals.
[58] He made his forward debut in the opening round of the 2023 AFL season against St Kilda,[59] collecting nine disposals and kicking a point.