Nathalie "Natacha" Régnier (born 11 April 1974) is a Belgian actress.

Born in Ixelles, a municipality of Brussels, she was attracted to theatre from early adolescence.

Her first screen role was in The Motorcycle Girl (1993), a short film by Stéphan Carpiaux.

In 1998 Régnier and Élodie Bouchez received the Prix d'interprétation féminine (Best Actress) at the 1998 Cannes Film Festival for their roles in La vie rêvée des anges by Erick Zonca.

Natacha Régnier was married to French musician Yann Tiersen, but they are now divorced.