The House of Natali was a noble family of the Republic of Ragusa.

They appear at the case nuove on 1297 of patrician nobility of the Republic of Venice.

They belonged to the list of late patriciate families of the Ragusan nobility.

Between the 14th and 16th century, the Natali family lived in Spalato (Split).

In 1817, Natali family received their confirmation of nobility from the Austrian Empire after the end the Republic of Ragusa.