In 2009, Gherman became Deputy Minister of Foreign Affairs and European Integration and Chief Negotiator on the Moldova–European Union Association Agreement, serving until 2013.

In February 2016, Gherman was nominated as Moldova's candidate for Secretary-General of the United Nations in the 2016 selection process for Ban Ki-moon's successor.

In 1999, she completed a Master of Arts (MA) postgraduate degree in war studies at King's College London.

[3] She began working in the Moldovan diplomatic service in 1991, as the second and then first secretary at the Department of International Organizations of the Ministry of Foreign Affairs.

For her "merits in promoting relations between Sweden and Moldova", Gherman was awarded the Order of the Polar Star at the rank of Commander 1st Class.

[3] In September 2017, she was appointed special representative and head of the UN Regional Center for Preventive Diplomacy in Central Asia with headquarters in Ashgabat, Turkmenistan.

[4][5] On 29 June 2009, she was appointed as Deputy Minister of Foreign Affairs and European Integration, to then-Minister Andrei Stratan.

In total, she spoke for over two hours, in what the campaign group 1 for 7 Billion called a "historic breakthrough and the additional transparency and scrutiny that comes with it.

[16] On the topic of sexual exploitation and abuse by UN peacekeepers, Gherman was asked multiple times about this problem during the United Nations informal dialogues.

"[18] She also said that member states needed to ensure that troops are well trained and held responsible in the case of abuse.