After finishing high school in Stuttgart, Wörner moved to New York City, where she studied acting at Lee Strasberg's Actors Studio.

In 2000, she returned to Germany, where she won a German television award, the Deutscher Fernsehpreis, for best leading actress.

[4] In 2009, Wörner played the role of Ellen in the TV miniseries The Pillars of the Earth, based on the eponymous book by Ken Follett.

In addition to her acting career, Wörner has been a goodwill ambassador for German charity Kindernothilfe since 2006.

In 2015, Wörner accompanied Foreign Minister Frank-Walter Steinmeier on an official trip to South Korea and Indonesia.