She is known for her roles as Stella Davenport in the medical drama The Royal from 2005 to 2008 and Alicia Metcalfe in the ITV soap opera Emmerdale from 2010 to 2015.

In 2015, she began appearing on the ITV talk shows This Morning and Loose Women on a recurring basis; Anderson also portrayed the role of Lexi Calder in the Channel 4 soap opera Hollyoaks from 2021 to 2022.

In 2023 Anderson took guest roles in Happy Valley and Boiling Point and appeared on stage at Hull Truck Theatre as Kayla in Anna Jordan’s two hander play Pop Music.

[3] In 2001, Anderson competed in Pop Idol; she narrowly missed out on a place in the live finals after finishing third in her group.

[13] Natalie played Maryanne Borden in the Liam Neeson action feature Memory, released 29 April 2022.