Bassingthwaighte rose to prominence in 2003 on the Australian soap opera Neighbours for her role as Izzy Hoyland, which earned her three Logie Award nominations.

After leaving Neighbours in 2006 to focus on her music career, Bassingthwaighte released a cover of "Don't Give Up" with Shannon Noll, which peaked at number two on the ARIA Singles Chart and was certified platinum.

Bassingthwaighte released her debut solo album 1000 Stars in 2009, which spawned the platinum top-ten hits "Alive" and "Someday Soon".

That same year, she made her debut as a television presenter, hosting So You Think You Can Dance Australia for its first three seasons, which earned her another three Logie Award nominations.

[5] Bassingthwaighte grew up in the suburb of Mount Warrigal as the second of four daughters with her older sister Melinda (born ca.

[7] Her first lead role was in the Asian production Chang & Eng, which depicts the biography of the first Siamese twins; Bassingthwaighte portrayed Adelaide Yates in both the Singapore and Bangkok seasons of the show.

[2] Bassingthwaighte had considered a music career for some years and had been a member of an R&B group, but it did not work out, and her interest focused on other options.

[2] By 2004, she had begun working on her own demos: songs with an acoustic-rock sound and, later that year, she was recruited as the lead singer for Australian electro-pop band, Rogue Traders.

[2] Formed in 2002 with James Ash on keyboards and Steve Davis on guitars, the group had used a variety of guest vocalists and issued a debut album before seeking a permanent singer.

[2] In May 2005, the band released "Voodoo Child" as their fifth single—the first with Bassingthwaighte—which reached number four on the ARIA Singles Chart and was certified platinum for shipments of 70,000 units in Australia.

In December 2006 she performed a duet with label mate Shannon Noll on their cover version of Peter Gabriel and Kate Bush's "Don't Give Up", for the various artists' album Home: Songs of Hope & Journey.

In October 2007 Rogue Traders released their third album, Better in the Dark, which spawned the hit singles "Don't You Wanna Feel" and "I Never Liked You"—both were certified gold, and "What You're On".

[27] It was used to raise awareness by the Aids Council of New South Wales for the 'Wear It With Pride' T-shirt campaign in the lead-up to that year's Sydney Mardi Gras parade.

[b][32] In January 2011, Bassingthwaighte returned to theatre, performing at the Sydney Opera House, in Love, Loss and What I Wore, a play "about women, their relationships and memories", where she co-starred with Judi Farr, Mirrah Foulkes, Amanda Muggleton and Magda Szubanski.

[37] In December 2014, Bassingthwaighte and other Australian singers recorded a cover version of Kate Bush's "This Woman's Work" under the name "Hope for Isla and Jude", and released it as a charity single to help raise funds for two siblings who suffer from the rare disease Sanfilippo syndrome.

[38] In September 2015, Bassingthwaighte reunited with her former band Rogue Traders, performing together for the first time in seven years, at a corporate show in Gold Coast.

[2] She gained greater popular acclaim on the Australian soap opera Neighbours, playing the role of Izzy Hoyland from 2003 to 2006.

Bassingthwaighte appeared in a documentary special celebrating the show's 30th anniversary titled Neighbours 30th: The Stars Reunite, which aired in Australia and the United Kingdom in March 2015.

[49][50] She reprised her role as Izzy Hoyland for a guest appearance on Neighbours in February 2018, and was again back for the final episodes of the series in 2022.

[51][52][53][54] In 2009, Bassingthwaighte starred in the Australian horror film Prey alongside Jesse Johnson, Christian Clark and Nicholas Bell, playing the role of Kate, an ambitious young surgeon working in the emergency department of a major city hospital.

[43][58] The Hakens are a real-life couple, where the husband, Trevor, became an informant and witness at the Wood Royal Commission into police corruption.

[60][61] In September 2017, she appeared in the second season of the drama series The Wrong Girl, playing the recurring role of pastry chef Gillian.

[69] Bassingthwaite's (previously Kills’) contestant, Beau Monga, eventually won the series, making it her only win as a coach in the history of the franchise.

[71] In May 2024, Network 10 announced that Bassingthwaighte would appear on the forthcoming eighth season of The Amazing Race Australia as a celebrity contestant alongside her sister Melinda Sheldrick.

[6] It was co-written, over two years, with her younger sister Nicole Moore, and is aimed at boosting teen and pre-teen girls' self-esteem.

The book features activities and is filled with pictures of Bassingthwaighte's life with her three sisters: Moore, Lisa Fogarty and Melinda Sheldrick.

[81] She encouraged fellow Australians to support the project to train health workers, village doctors and caregivers and reduce the impact of pneumonia.