Natalie Shirley (born 1957) is an American lawyer and businesswoman and university president from Oklahoma.
Shirley joined the Washington, D.C., firm ICI Mutual Insurance Group and served ICI in a variety of positions over a 16-year period, including Executive Vice President, chief operating officer, and General Counsel.
Shirley's investiture as the fourth president of OSU-OKC was held on March 12, 2012, at St. Lukes United Methodist Church during a week of celebration marking the 50th anniversary of the school.
In January 2015, Shirley was appointed by Governor Mary Fallin to serve in her Cabinet as Secretary of Education and Workforce Development.
Later in 2007, Commerce Department Director Amy Polonchek resigned to accept a position with the Meridian Technology Center for Business Development.