She is best known for her roles as Nadja in the FX comedy horror series What We Do in the Shadows (2019–2024) and Sophie in the Channel 4 sitcom Stath Lets Flats (2018–2021).

[9] She was a longtime member of sketch comedy troupe Oyster Eyes[10] and has written for Anna & Katy and The Midnight Beast.

[11] In 2015, she was in the comedy sketch show pilot of People Time on BBC Three with Ellie White, alongside her brother Jamie Demetriou, with Claudia O’Doherty, Liam Williams, Alistair Roberts and Daran Johnson.

[13] Since March 2019, Demetriou has starred as Nadja, a Greek Romani vampire,[14][15] in the critically acclaimed FX horror comedy series What We Do in the Shadows.

[20][19][21] Starting 18 May 2020, Demetriou and Vic Reeves co-hosted Netflix's unscripted reality competition show The Big Flower Fight.