It is part of the Natchez-Adams School District and serves students in grades nine through twelve.

[4] There were a total of 1,169 students enrolled in Natchez High during the 2006–07 school year.

The gender makeup of the school was 52% female and 48% male.

The racial makeup of the school was 90.4% black, 9.3% white, and 0.3% Hispanic.

[5][6] The former location of Natchez High School was at 64 Homochitto Street, it also known as Margaret Martin High School, and it was a public high school "for white students-only".