Sudfeld also spent four seasons with the Philadelphia Eagles as a backup quarterback, seeing occasional playing time and was a part of their Super Bowl LII-winning team.

[1] During his time there, he threw for 3,300 yards, 33 touchdowns, and 16 interceptions,[2] earning the Trans Valley League Outstanding Offensive Player award,[3] second-team all-state and first-team all-district honors as a senior.

[6] Sudfeld got experience with the Hoosiers as a true freshman, in relief duty of Cameron Coffman, after starter Tre Roberson suffered a broken leg.

[10] In Sudfeld's junior year, after both Cameron Coffman and Tre Roberson transferred to Wyoming and Illinois State respectively,[11][12] he completed 60.5 percent of his passes for 1,151 yards with 6 touchdowns and 3 interceptions as the undisputed starter, before injuring his left shoulder against Iowa, which required surgery, forcing him to miss the rest of the 2014 season.

[23] Sudfeld did not see any playing time his rookie year, as he was inactive for all 16 games as the team's third-string quarterback behind starter Kirk Cousins and primary backup Colt McCoy.

He saw significant playing time during the season finale, completing 19 of 23 passes for 134 yards as the Eagles lost to the Dallas Cowboys by a score of 6–0.

[28] In the NFC Championship against the Minnesota Vikings, he appeared in his first playoff game late in the 4th to take a knee down since the Eagles already locked up the 38–7 victory.

[30][31] On December 30, 2018, Sudfeld came into the game against his former team to replace an injured Nick Foles and threw his first career touchdown pass to Nelson Agholor.

[35] During the last game of the 2020 regular season against the Washington Football Team, Pederson replaced starting quarterback Jalen Hurts with Sudfeld early in the fourth quarter.

[40][41] After rookie quarterback Trey Lance suffered a sprained knee, Sudfeld was elevated to the active roster as the second option behind incumbent starter Jimmy Garoppolo in a Week 7 matchup against the Indianapolis Colts.