The Nathaniel Irish House is an historic, American home that is located in the Queen Village neighborhood of Philadelphia, Pennsylvania.

Thomas Moore House, this historic structure was built between 1763 and 1769, and is a 3+1⁄2-story, three-bay, brick rowhouse.

It has a two-story, attached rear building and a steep gable roof with dormers.

This residence and the adjoining houses were built by Nathaniel Irish.

It is located in Philadelphia's South Front Street Historic District.