Óscar Berger ran as the party's presidential candidate in the 1999 Guatemalan General Election becoming the runner-up in 1999.

However, internal divisions plagued the party and Óscar Berger decided to leave PAN and enter the second round of the 2003 presidential elections as the candidate for the Gran Alianza Nacional (GANA), an alliance of 3 parties including Partido Patriota (PP), Movimiento Reformador (MR) and Partido Solidaridad Nacional (PSN).

At the 2003 elections, held on 9 November 2003, the party won 8.4% of the popular vote and 17 out of 158 seats in Congress.

At the 2007 elections, the party was badly defeated, but still received representation in Congress with 4.58% of the vote and three seats.

In the 2011 Election, the party chose Juan Guillermo Gutiérrez as its presidential candidate.