The National Bank of Commerce Building is a historic commercial building at 200 S. Pruett St. in downtown Paragould, Arkansas.

It is a two-story structure, built out of cut stone, with a center entrance recessed in a two-story opening with flanking Ionic columns.

This Classical Revival style building, probably the finest of its style in Greene County, and the least-altered bank building of the period in Paragould, was designed by the Memphis firm of Hankers and Cairns and was built in 1923.

[2] The building was listed on the National Register of Historic Places in 1993.

This article about a property in Greene County, Arkansas on the National Register of Historic Places is a stub.