The National Brewing Company plant was located between Dillon, Conkling and O'Donnell Streets in the Baltimore's Highlandtown neighborhood.

In 1885, the Wunder Brewery was sold at foreclosure sale to members of the Straus family, who later incorporated the business as the National Brewing Company.

In 1899 National was one of sixteen breweries that joined to form the Maryland Brewing Company, with the then massive combined annual production capacity of 1,500,000 barrels.

[5] In the early 1930s Samuel H. Hoffberger, in anticipation that Prohibition would be repealed, began the process of acquiring the National Brewery.

[6] Hoffberger, a lawyer with numerous business and civic interests, revived the National Brewing Company and modernized its brewery.

[6][9] The one-eyed Mr. Boh, with his handlebar mustache, would be featured prominently in National Bohemian advertising for many years.

[10] In 1947, after the death of Arthur Deute, Jerold was named President of the National Brewing Company, a position he would hold for 28 years.

“Natty Boh” was sold at Memorial Stadium and would ultimately become the official sponsor of the Baltimore Orioles.

[13][14] In October 1958 the company launched a new advertising campaign praising the Chesapeake Bay region and describing National Bohemian beer as being “From the Land of Pleasant Living.”[15] The slogan became part of the folk culture of Maryland and the unofficial motto of the state.

[18] By the early 1970s, the National Brewing Company, facing intense competition and high prices, struggled to continue operating as an independent entity.

[24] Nevertheless, as Carling-National experienced a sharp decline in sales their first year, a merger with Pabst Brewing Company was subsequently proposed.

In the early 2000s the old Baltimore National Brewing plant was converted to business and office spaces as a part of the Brewers Hill redevelopment project by Obrecht Commercial Real Estate.

[26] In late 2011, it was announced that the National Premium label would be revived under the ownership of an Easton, Maryland, based entrepreneur.