The Faculty of Medicine is the academic centre for medical and clinical research and teaching at Imperial College London.

[6] To accommodate medical activities at South Kensington, the Sir Alexander Fleming building was opened in October 1998, designed by Foster + Partners and costing £65 million.

[1][8] In early 2020, immunology research focused on finding a vaccine against SARS-CoV-2 as part of the inter-departmental COVID-19 Response Team, led by the faculty.

[13] The medical school is based at the Sir Alexander Fleming Building on Imperial College Road in South Kensington.

[21][22] The Department of Brain Sciences is the centre of research and teaching in neuroscience and mental health at Imperial College London.

[29] The department also hosts the Imperial College Brain Tumour Research Centre of Excellence, led by Dr Nelofer Syed.

[38] The School of Public Health is the faculty's research centre for epidemiology and public health, and includes the Jameel Institute for Disease and Emergency Analytics (established with support from Community Jameel, and led by Neil Ferguson), and the Medical Research Council's Centre for Global Infectious Disease Analysis.

The National Heart and Lung Institute was the highest ranked of Imperial's medical departments in Research Excellence Framework (REF) 2014.