The first exhibits were initially housed in a room in the Palace of the Bishopric of Cenad and consisted of donations, adventitious archeological discoveries and acquisitions.

In 1896, the Museum of Banat participated in the Budapest Millennium Exhibition [hu] with several objects, winning a bronze medal and a certificate of appreciation.

[2] After Banat came under Romanian administration as a result of the Treaty of Trianon on 4 June 1920, a restructuring of the museum took place under Emanuil Ungureanu [ro], cultural inspector of Timișoara in the interwar period.

Romanian personalities who are credited with the Museum of Banat were Ioachim Miloia, Dionisie Linția [ro], Aurel Ciupe, Marius Moga and Constantin Daicoviciu.

[3] Until 2000, it included the following departments: History, Natural Sciences, Art, Ethnography, Banat Village Museum and Zonal Restoration Laboratory.