[5][6] The museum featured exhibits on colonial crime, pirates, Wild West outlaws, gangsters, the Mob, mass murderers, and white collar criminals.

Visitors to the museum were guided through the process of solving the crime through forensic science techniques, including ballistics, blood analysis, fingerprinting and footprinting, and dental and facial reconstruction.

[9] The crime-fighting gallery drew attention to such notables as founding FBI Director J. Edgar Hoover, and the legendary law enforcement agent Eliot Ness.

At one time, the museum also served as the taping facility for Fox's America's Most Wanted beginning in 2008, which recorded during its first run in studios throughout the Capital Region.

Surrounding the studio were exhibits on the National Center for Missing and Exploited Children and McGruff the Crime Dog, as well as a Cross Match Technologies station for child fingerprinting.