[1] The museum has many artefacts related to archaeology, history, art, and handicrafts and also has information about ruins, graveyards, buildings etc.

[3] The museum's first exhibition opened in 1965 in Greenland's Moravian Brethren Mission House.

It moved to its present location in Nuuk's old colonial harbor in the 1970s due to the expansion of its collection with repatriated native Inuit items from the National Museum of Denmark.

The museum holds the mummies of three women and a six-month-old child dating to the mid-15th-century.

Several other nearby buildings also fall under the museum's protection, such as the restocked cooper's workshop and a display on blubber vats and presses.