The league is officially affiliated to the United States Adult Soccer Association (USASA) and has automatic qualification for the U.S. Open Cup.

The National Premier Soccer League is divided into four separate regions (Northeast, South, Midwest, and West).

The regular season runs from May to July with the exception of the West Region that has historically started in late March or early April.

[2] The NPSL currently has automatic berths in the U.S. Open Cup where they gain eligibility towards the CONCACAF Champions League.

Since its inception, the league has managed to place at least one team actively playing under its banner into U.S. Open Cup competition.

The recent success of the NPSL in USASA qualifying has encouraged a movement by which the league could have automatic berths in the final tournament.

However, the USASA sanctions affiliated, but separately run, national leagues that are recognized in practical terms as playing at a higher level than the USASA state association leagues; for example, they receive automatic berths to the US Open Cup.

[4] The National Premier Soccer League attracts top amateur talent from around the United States.

The first conference will be the Pacific Conference and will exist of the following six teams: JASA Redwood City, Marin County SC, Racing Sacramento City FC, Real San Jose, San Leandro United FC, and Yemen United California.

Each year the member clubs help elect a chairman, treasurer, and secretary and an eight-member board of directors.

Renegade GK, hummel, MyCujoo, Passage, Carbon Athletics, GCG Sports, Activate Canopy, and HomeLight are all listed as current business partners (2021).

[57] However, following the departure of numerous previously announced teams and issues in launching the professional league the tournament was altered.