National Register of Historic Places listings in southern Puerto Rico

This is a list of properties and districts in the southern municipalities of Puerto Rico that are listed on the National Register of Historic Places (Spanish: Registro Nacional de Lugares Históricos).

It includes places along the southern coast of the island, and on the south slope of Puerto Rico's Cordillera Central.

The area covered spans from the city of Yauco on the southwest coast to the Guayama municipality at the southeast.

Names of places given are as they appear in the National Register, reflecting name as given in NRHP application at the date of listing.

Note, the National Register name system does not accommodate Spanish á, ñ and other letters.