The National Shrine of Saint Elizabeth Ann Seton is a U.S. religious site and educational center in Emmitsburg, Maryland, that pays tribute to the life and mission of Elizabeth Ann Seton (August 28, 1774 – January 4, 1821), the first native-born citizen of the United States to be canonized by the Roman Catholic Church.

Born of a prominent Anglican family in New York City, Elizabeth Ann Bayley Seton was received into the Roman Catholic faith at Saint Peter's Church, Barclay Street in lower Manhattan, March 14, 1805.

Samuel Sutherland Cooper, a wealthy convert and seminarian, bought 269 acres of land for an establishment for the sisterhood near Emmitsburg in the countryside of Frederick County, Maryland.

[2] The former Fleming farmhouse, informally called the "Stone House", built in 1750 near Toms' Creek, served as the first headquarters of the community.

[3] In the first winter there, the wind blew in icy drafts through the chinks of the building, and the occupants sometimes awoke to find a blanket of snow had drifted into the rooms during the night.

In mid-October 1809, Archbishop John Carroll of Baltimore, who had come to administer Confirmation to the children, determined that the building was unsuitable, and directed the erection of a new log structure, now called the "White House.

The formal designatation ceremony took place on August 4, 1991, under the guidance of Archbishop Agostino Cacciavilan, the Apostolic Pro-Nuncio to the United States.