The National Society of Operative Printers and Assistants (NATSOPA) was a British trade union.

In 1911, it assumed its long-term name, the "National Society of Operative Printers and Assistants".

In 1966, the union merged with the National Union of Printing, Bookbinding and Paper Workers, becoming Division 1 of the Society of Graphical and Allied Trades (SOGAT), but in 1970 the failure to agree a common rulebook led to Division 1 leaving to become the National Society of Operative Printers and Media Personnel.

The union sponsored George Isaacs as a Labour Party candidate in each general election and two by-elections between 1918 and 1955.

This article related to a United Kingdom trade union is a stub.