The National Teachers' Normal and Business College Administration Building, at 158 E. Main St. in Henderson, Tennessee, was built in 1908.

It was listed on the National Register of Historic Places in 2012.

[1] It was designed by Memphis architect Hubert T. McGee in Renaissance and/or Italianate style.

[1] It was a main building of the National Teachers' Normal and Business College, which was incorporated in 1907 as a successor of the West Tennessee Christian College, itself the successor of the Henderson Male and Female Institute.

[2] The entire structure (aka, Old Main) underwent a thorough renovation which was completed in 2019.