The Pennsylvania Railroad had a train station in Natrona at Vine and Federal streets; its rail line began running through the town in the mid-19th century.

The Interstate Commerce Commission required that the ailing New York, New Haven and Hartford Railroad be added in 1969.

The West Penn Railways provided electric street car service to Natrona from 1906 until 1937.

Air pollution levels (particularly chromium) measured in Natrona area schools are among the worst in the United States.

[15] The film Knightriders (1981) by George A. Romero starring Ed Harris used scenes shot on Garfield Street in Natrona (1980) for the movie.