In 1999, he joined Dream Theater's co-founder and then drummer Mike Portnoy, together with Flower Kings' Roine Stolt and Marillion's Pete Trewavas they formed the super-group Transatlantic.

[1] During his twenties he wrote two musicals (Hit Man and Homeland), did some session jobs, tried to get a deal as a singer-songwriter in Los Angeles, and recorded a few country and western demos with his brother Richard.

After about ten years, having played in small Californian clubs with various groups including Burlesque, Morse founded Spock's Beard together with his brother Alan, to give voice to his great passion for Progressive Rock.

His brother Richard advised him to go to Germany to play hit songs as a one-man band in pubs, accompanying himself with piano or guitar, to generate income.

[2][page needed] The popularity of Spock's Beard's continued to grow and they would soon become one of a number of successful progressive rock bands during the late nineties (along with Dream Theater, Porcupine Tree, and The Flower Kings).

In 1999, he joined former Dream Theater co-founder Mike Portnoy, Flower Kings' Roine Stolt and Marillion's Pete Trewavas to form the supergroup Transatlantic.

In concert, the group has included Daniel Gildenlöw of Pain of Salvation, and occasionally Ted Leonard, Morse's eventual replacement in Spock's Beard.

In 2003, Morse, Mike Portnoy, Paul Gilbert and Matt Bissonette formed Yellow Matter Custard as a Beatles tribute supergroup.

In 2014, he gave life to another group, The Neal Morse Band (with Mike Portnoy, Randy George, Eric Gillette and Bill Hubauer), that released its first studio album The Grand Experiment in 2015.

The period leading to this decision is described on the solo album Testimony (2003), an epic, introspective composition which features Kerry Livgren of Kansas and Mike Portnoy.

However, before Jayda received surgery, the hole disappeared following a church service in which Morse's wife and others prayed for God's healing.

The studio band is Neal, Mike Portnoy, and Randy George with guests Mark Leniger, Alan Morse, Roine Stolt, Steve Hackett, and Jordan Rudess.

In early 2007, Morse released Sola Scriptura, a concept album detailing the life and struggles of the German theologian Martin Luther, and corruption within the medieval Church.

During his early solo years, Morse focused most of his touring in Europe and had a band made largely of European musicians.

In 2000, Morse provided vocals for the song "The First Man on Earth" on The Universal Migrator Part 1: The Dream Sequencer, one of Arjen Anthony Lucassen's Ayreon albums.

Morse has been a guest musician on several 2005 albums, including Ajalon's Threshold of Eternity, Roine Stolt's Wallstreet Voodoo, Salem Hill's Mimi's Magic Moment, and Mark Leniger's Walk on Water.

[9] In 2014, Morse created Morsefest, a weekend concert festival held at his local church, New Life Fellowship, in Cross Plains, TN.

[10] The inaugural Morsefest occurred on November 14–15, 2014 and featured the Testimony and One albums played in their entirety with string, horn, percussion, and choir sections as well as a morning Inner Circle acoustic show.

[12][13] In 2023, in addition to the show in Tennessee, Morse took Morsefest on the road to Europe for the first time to The Boerderij in Zoetermeer, Netherlands and again in 2024 to Trinity Church in Essex, United Kingdom.