The league had members, as its name suggests, in the state of Nebraska.
[1] The public colleges in the conference departed for the separate Nebraska Intercollegiate Athletic Association (NIAA) in 1928 but re-joined after 1942.
In November 1959, the Nebraska College Conference accepted the withdrawal of Concordia College (now known as Concordia University Nebraska), Dana College, and Midland College (now known as Midland University).
Those three schools joined the Tri-State Conference at its formation in 1960.
[2] Nebraska Wesleyan University left in 1969 to join the newly formed Nebraska Intercollegiate Athletic Conference (NIAC) (now called the Great Plains Athletic Conference (GPAC)).