Nebraska Highway 10 begins at the Kansas border south of Franklin.

From there it runs west, concurrently, with Interstate 80 to interchange 275, just east of the Great Platte River Road Archway Monument.

Highway 10 then crosses over US 30 at a grade separation with access provided by Link 10-F just to the north.

[2] Here, it turns north again, goes through Pleasanton, then meets Nebraska Highway 2 at Hazard.

[3] This replaced the former route of Highway 10 which crossed I-80 at interchange 279 to meet US 30 east of Kearney.