Neffsville is an unincorporated community in Manheim Township, Lancaster County, Pennsylvania, United States.

Manheim Township School District serves 5,400 students with 637 employees, 423 of them holding teaching certificates.

According to local tradition, Neffsville was named for the family of Johan Christian Neff, originally from Gerolsheim, Germany, who was aboard the ship Lydia when she arrived in Philadelphia on September 19, 1743.

Neff moved to Lampeter Township in Lancaster County, married the former Frena Howery, and they had three children there - Christian in 1750, Henry in 1754, and Esther in 1757.

The product is still made today, and Shank's is now the second-largest primary vanilla supplier in North America, as well as supplying other extracts, flavorings and spices.