[1] It was the site of ancient Casae Nigrae, a settlement of Roman North Africa with an attached bishopric that remains a Latin Catholic titular see.

Average annual rainfall is between 5 and 20 millimetres (0.20 and 0.79 in) with the winter being the main wet season.

[5][6][7] Negrine was known as Casae Nigrae during the time of the Roman, Byzantine and Vandal empires (30 BC – AD 640).

[10][11][12] The town was the seat of one of many suffragan bishoprics in Numidia during Roman and Vandal times.

[13] Known residential bishops include : In 1933 the diocese was nominally restored as a Latin Titular bishopric in the Roman Catholic Church, named Casæ nigræ (Latin) / Case nere (Curiate Italian).