Neißemünde (Neissemuende, literally Mouth of the Neisse river) is a municipality in the Oder-Spree district, in Brandenburg, Germany.

The municipal area is located in the historic Lower Lusatia region, close to the border with Żytowań in Poland.

The region along the Oder and Neisse rivers was settled by Polabian Slavs (Sorbs) from about 600 onwards and in 965 became part of the Imperial March of Lusatia.

The village of Ratzdorf was heavily affected by the 1997 Central European flood; reconstruction was funded, inter alia, through a substantial donation by US singer Michael Jackson.

After World War II, Breslack, Coschen, Ratzdorf and Wellmitz were incorporated into the State of Brandenburg from 1947 to 1952 and the Bezirk Frankfurt of East Germany from 1952 to 1990.