Neil Alexander Steven Brockdorff (born 1958) is a British biochemist who is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.
[7] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.
[7][8] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.
[9][10] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.
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