Nemesis 2 (グラディウス2, Guradiusu Tsū, Gradius 2) is a side-scrolling shoot 'em up video game released for the MSX computer in 1987 by Konami.

Also, when the bosses are being defeated, if the Metalion flies where they are, a mini-level can be accessed in order to obtain new permanent upgrades, if the mini levels are successfully cleared.

The Director General of Space Science Agency Dr. Venom was exiled to Planet Sard for a failed coup d'état.

The Nemesis High Council sends James Burton, ex-pilot of the Vic Viper, to pilot Metalion and attack Dr. Venom and the Bacterion invaders.

This X68000 port is essentially an enhanced remake of Nemesis 2 with graphical quality on par with Gradius III.