During the Prussian Crusade from about 1200 onwards, the area of the local Baltic Skalvian and Curonian pagans was conquered by German military orders, at first by the Sword Brethren, after the 1236 Battle of Saule by the Teutonic Knights.

[1] After the subsequent Thirteen Years' War (1454–1466) the settlement was a part of Poland as a fief held by the Teutonic Knights,[2] and thus was located within the Polish–Lithuanian union, later elevated to the Polish–Lithuanian Commonwealth.

A part of the Province of East Prussia until after World War I, in 1920 Nemirseta was with the Klaipėda Region (Memelland) separated from Germany according to the Treaty of Versailles.

After World War II, according to the 1945 Potsdam Agreement, the region again became part of Lithuania, although as the Soviet-controlled Lithuanian Soviet Socialist Republic and the remaining German population was expelled.

Part of a large Soviet Army proving ground, the place now called Nemirseta finally lost its meaning as a German border town and most of the buildings were demolished.