Nemuro Station has a single side platform.

The station serves as Nemuro's central bus terminal, with scheduled overnight service to Sapporo via Nakashibetsu, two or three daily services to Kushiro, and multiple daily services to Nakashibetsu Airport, as well as local bus routes.

Sightseeing buses operate to Cape Nosappu during summer months.

It was the easternmost train station in Japan from 1921 to 1929, when a new railway opened to Habomai on the Nemuro Peninsula, and again from 1959, when the Habomai railway closed, until 1961, when Higashi-Nemuro Station opened on the eastern approach to Nemuro.

This Hokkaido rail station-related article is a stub.