The station has served both as an important part of the railroad's northern operations and as a terminal for its riverboat service on the Yukon River.

On November 11, 2020, the Friends of the Tanana Valley Railroad (FTVRR) signed with the City of Nenana to become the new caretakers of the depot.

[3] The FTVRR will reopen the depot as a museum after repairs and renovations.

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