She served as Yahya Jammeh's last Minister of Foreign Affairs from 2015 to 2017 and as Gambian Ambassador to the United States in 2009.

She was then appointed as the Secretatary of State for Communication and Information Technology, serving until 19 March 2008,[3] when she was replaced by Fatim Badjie.

At the same time, Musa Mboob, former Inspector General of Police, was appointed as Deputy Ambassador to the United States.

[2][3] On 5 January 2015, MacDouall-Gaye was appointed as Minister of Foreign Affairs, replacing Bala Garba Jahumpa.

[7] On 16 January 2017, during the 2016–2017 Gambian constitutional crisis, MacDouall-Gaye issued her letter of resignation to President of the Gambia Yahya Jammeh.