Neopets is aimed at a slightly younger audience than other Wizards of the Coast offerings such as Magic: The Gathering.

Most deck-building articles suggest a limit of 2-3 species for the Basic Neopets, along with a minimum of 20 Item and/or Equipment cards (essentially half of the deck).

An Experienced Neopet has higher attributes, and often has helpful special abilities that influence various part of the game.

A player must "bank" 21 points worth of Items and Equipment cards in order to win the game.

The Location can give an advantage to a certain kind of Neopet, or can cause some side effect to any battles occurring there.

Because Curse cards typically remain in play, they can cripple a given Neopet's ability to perform effectively.

For example, a given Constellation might confer an additional power to the Neopets in play, or otherwise might change the game in some fashion.

Only three Neopets species did not make it into the TCG, as produced by Wizards of the Coast: Gnorbu, Ogrin, and Xweetok.

The Basic Neopet types that were introduced were Aishas, Korbats, Myncis, Scorchios, Shoyrus, Kacheeks, Acaras, Lupes, Wockies, Poogles, Eyries, and Grarrls.

This expansion's release was coordinated with an online plot/war, which was set in the virtual feudal-themed land of Meridell.

This expansion's theme was space, providing players with futuristic and robotic items and equipment.

Six new Neopet species made their debut in this expansion (Basic Type: Cybunny, Grundo, Jetsam, Jubjub, and Kougra).

Revolving around a central popular game character known as Hannah the Usul, a substantial plot was released on the Neopets website along with this 150-card set; it was also the first set to have "secret" cards (5 Jelly cards 151/150-Jelly Poogle, 152/150-Jelly Shoyru, 153/150-Jelly World, 154/150-Jelly Puppyblew, and 155/150-Orange Jelly).

This 120-card expansion revolved around the underwater city of Maraqua, which was rebuilt during the plot of the same name on the Neopets website.

Four new Neopet species were released with this set, including the Yurble (other Basic Type: Chomby, Lenny, and Tuskaninny).

The general theme of this set is about encouraging fans to re-live past plots, or, for those new to Neopets, catch up to them with some of the more well-known aspects of the series.

This deck is associated with the plot, Tale of Woe; where a village has fallen under a curse, and only the Neopets can determine what happened to the townsfolk.