The neighbours are Neu-Ulm, Elchingen, Bibertal and Pfaffenhofen an der Roth.

Through the area of Nersingen flow three rivers: The Danube in the north and her both supply rivers, Roth and Leibi, which cross Nersingen from south to north.

Also, there are some water ditches and some excavator lakes, which resulted from gravel quarrying.

Hilti AG in Straß Nersingen lies next to the Bundesautobahn 7 and the train line Ulm - Munich.

The Bundesstraße 10 passes the municipality parts Unterfahlheim, Oberfahlheim and Nersingen.