[3] She was bought by Ashview Farm's agent on behalf of Repole Stable, Eclipse Thoroughbred Partners & Michael House, for US$350,000 at the 2020 Keeneland September Selected Yearling Sale.
[5] Nest began her racing career on September 25 in a Maiden Special Weight event over 1+1⁄16 miles at Belmont Park against four other experienced fillies.
Starting as the 19/20 odds-on favorite eased back off the pace while showing early speed, taking the lead with two furlongs to run and widening her margin of victory to 5 lengths in a time of 1:43.88.
[7] Todd Pletcher entered Nest in the Grade II Demoiselle Stakes at Aqueduct Racetrack on December 4 over the longer distance of 1+1⁄8 miles.
Nest went off as the narrow 8–5 favorite and was forced to take the overland route around the track while carried five wide around the clubhouse turn, settled a few lengths back in fourth position.
Jockey Irad Ortiz Jr. shook up Nest after a dawdling three-quarters in 1:15.80, and she loomed four wide into the lane to challenge Venti Valentine and Magic Circle in a stretch duel to the finish.
Pletcher said Nest would join his string at Palm Beach Downs for the winter after earning 10 points on the Road to the Kentucky Oaks.
Starting as the 3/10 odds-on favorite she settled into a stalking position in third early under jockey Irad Ortiz Jr. Longshot Mining Chrome cruised through a moderate fractions, but into the run for the far turn, Nest, pounced on the leaders and took charge.
Then she overcame a wide trip to reel in pacesetting Interstatedaydream late on the second turn and powered her away for easy 8+1⁄4 lengths victory in 1:44.16 on a track that was official noted as Wet Fast.
On June 11 entered the Belmont Stakes and faced her stablemate Mo Donegal and 2022 Kentucky Derby winner Rich Strike and five other horses.
Jose Ortiz angled her out four to five wide straightened away into upper stretch, and ran on to chase Mo Donegal to finish second best, three lengths behind her stablemate.
[15] On July 23 Nest clashed with her rival Secret Oath in the Grade 1 Coaching Club American Oaks at Saratoga Race Course.
Todd Pletcher was originally going to wait for the GI Alabama Stakes August 20 because he wanted to give his filly time to recover from the grueling Belmont against the colts and geldings.
Nest made the lead approaching the quarter pole, and regular jockey Ortiz, who had been warned by trainer Todd Pletcher for an outside run from Secret Oath turning for home, let his filly roll.
[17] On October 9, Nest faced old horses in the Grade II Beldame Stakes at Aqueduct for the first time in a small field of five runners.
"[18] On November 5 in the Breeders' Cup Distaff, Nest started as the 3/2 favorite but finished fourth behind winner and stablemate Malathaat after staging a mild rally mid-race.
[20] Nest was rested for several months after the Breeders' Cup, and published her first workout of 2023 in April at the Palm Beach Downs training center in Florida.
Pletcher added it was not certain that Nest would be retired, and had even suggested that co-owner Mike Repole could buy out his partners at the auction for sole ownership of the horse.