The league was commenced playing at the 2005–06 season, replacing the Super Cup as the elite netball competition in England.
From 2016-21 the league was sponsored by VitalityHealth and, as a result, it was known as the Vitality Netball Superleague.
Historically the league's most successful teams are Team Bath, who have won five titles, and Saracens Mavericks, who have played in seven grand finals.
In more recent times, Surrey Storm won successive titles in 2015 and 2016 and Wasps have played in three successive finals, winning two titles, between 2017 and 2019.
Umpire Gary Burgess made history in 2018 by umpiring his 10th consecutive Netball Superleague final between Manchester Thunder and Surrey Storm.