Netcott-Pfeiffer House is a historic building located in Parkersburg, Iowa, United States.

George A. Netcott sold the house in 1896 to Gustavus A. Pfeiffer, a pharmacist, and his brother Paul, a local banker and land baron.

The brothers, who were also humanitarians and philanthropists, lived here together with their families until Gustavus moved to St. Louis in 1901.

The house is also associated with physicist Edwin Thompson Jaynes, who lived here from 1929 to 1942 with his mother after his father's death.

This article about a property in Butler County, Iowa on the National Register of Historic Places is a stub.