There is some evidence of a deserted medieval village at Nethercote, lying to the south of the modern hamlet.

[4] Throughout the Middle Ages until the mid-eighteenth century, Nethercote and the neighbouring hamlets of Grimsbury and Huscote were the centre of Banbury's cheese making trade.

The cheese was made from local resources and much prized at the time, although there is little mention of it by the nineteenth century.

[5] Klaus Fuchs is said to have handed over the secret formula of the atom bomb to a Russian spy on a bench in Nethercote in 1945.

[6] Nethercote and the neighbouring hamlet of Grimsbury formed part of the ancient parish of Banbury.

[24] In 2004, Thames Valley Police raised a road traffic order preventing vehicular access to the hamlet from the A422.