S10's appointment as the Dutch representative was announced on 7 December 2021, while the song, "De diepte", was presented to the public during an event on 3 March 2022.

Performing during the show in position 8, "De diepte" was announced among the top 10 entries of the first semi-final and therefore qualified to compete in the final on 14 May.

The Netherlands has used various methods to select the Dutch entry in the past, such as the Nationaal Songfestival, a live televised national final to choose the performer, song or both to compete at Eurovision.

In 2013, the internal selection of Anouk performing "Birds" managed to take the country to the final for the first time in eight years and placed ninth overall.

Each artist and songwriter was able to submit a maximum of three songs and entries with "a contemporary, but in any case authentic sound" were preferred.

[11] The selection of S10 as the Dutch representative occurred through the decision of a selection commission consisting of AVROTROS general director Eric van Stade, television host and author Cornald Maas, singer and television host Jan Smit, radio DJs Coen Swijnenberg [nl] and Sander Lantinga, and Dutch Eurovision delegation member Joyce Hoedelmans from four entries shortlisted among 400 submissions received by the broadcaster, one of which was performed by Dani van Velthoven, winner of the eleventh season of the reality singing competition The Voice of Holland.

"[14] On 3 March 2022, S10's Eurovision entry, "De diepte", was presented to the public during an event that took place at the Tuschinski Theatre in Amsterdam.

The song was premiered at the same time during the NPO Radio 2 programme Aan de slag!, hosted by Bart Arens.

On 9 April, S10 performed during the Eurovision in Concert event which was held at the AFAS Live venue in Amsterdam and hosted by Cornald Maas and Edsilia Rombley.

[19] According to Eurovision rules, all nations with the exceptions of the host country and the "Big Five" (France, Germany, Italy, Spain and the United Kingdom) are required to qualify from one of two semi-finals in order to compete for the final; the top ten countries from each semi-final progress to the final.

On 25 January 2022, an allocation draw was held which placed each country into one of the two semi-finals, as well as which half of the show they would perform in.

[29] At the end of the show, the Netherlands was announced as having finished in the top 10 and subsequently qualifying for the grand final.

Voting during the three shows involved each country awarding two sets of points from 1-8, 10 and 12: one from their professional jury and the other from televoting.

[34][35] The Dutch jury consisted of Andrew Makkinga, Barry Paf, Eva van Manen, Kris Berry, and Perquisite.