The Neusiok were an Indigenous people of the Southeastern Woodlands in present-day North Carolina.

The Neusiok lived along the southern banks of the Neuse River, primarily in what are now Craven and Carteret counties.

[1] English explorers Philip Amadas and Arthur Barlowe wrote about the Neusiok in their 1584 expedition.

[1] In one account, Wingina, Weroance of the Secotan (Roanoke), explained his own tribal history, in relation to the Neusiok, his neighboring tribe, referred to as the "Neiosioke" by Barlowe.

An unspecified number of Secotan men and 30 women attended a feast in the town of Neiosioke.