Neuvy-Saint-Sépulchre (French pronunciation: [nøvi sɛ̃ sepylkʁ] ⓘ) is a commune in the Indre department in central France.

The town takes its name from its basilica, dedicated to Saint James the Great (French: Basilique Saint-Jacques), which is a replica of the Church of the Holy Sepulchre in Jerusalem.

The construction of an original church was finished in 1049; it was dedicated to Saint James the Greater (Saint-Jacques-le-Majeur in French).

The building of a new church modelled on the Saint Sepulchre was instigated by the cardinal Eude de Châteauroux upon his return from the crusades.

The church is surmounted by a dome with a diameter of 22 m. The site of the replica of the Holy Sepulchre lay in the middle of a rotunda of, at ground level, eleven columns representing those Apostles left after the betrayal of Jesus by Judas Iscariot.