It connects the northern reaches of Lake Mead National Recreation Area to Interstate 15 (I-15) via Moapa Valley and the communities of Overton and Logandale.

From this point, SR 169 winds northward approximately 5 miles (8.0 km) before entering the rural town of Overton and becoming Moapa Valley Boulevard.

[2][3] On the southern outskirts of Overton, the route passes by the Lost City Museum, a historical landmark built on the site of an Anasazi village called Pueblo Grande de Nevada that was estimated to have been settled circa 300–500 BC.

[4] As SR 169 travels northward through Overton, it forms the main road through the rural town while paralleling a Union Pacific railroad line to the west and the Muddy River to the east.

[8] The eastern end of SR 12 was removed from maps by 1940, leaving a 24-mile (39 km) paved route from Lake Mead (near the St. Thomas site) to US 91.