The route was originally part of mainline US 395 before it was realigned around Carson City along I-580.

Although still signed as US 395 Business, the route is no longer part maintained by the Nevada Department of Transportation (NDOT) and the ownership has been transferred to Carson City.

begins at an intersection with I-580 north/US 50/US 395 on the south side of Carson City.

The route is a major arterial thoroughfare within the urban area.

At their meeting on November 14, 2018, NDOT's Board of Directors voted to transfer ownership of the remainder of SR 529 (between I-580 and Fairview Drive) to Carson City, in order to facilitate the city's goal to construct a complete streets project on South Carson Street.