From State Route 321 in Pioche, State Route 322 passes by U.S. Route 93 and heads to the entrance of Spring Valley State Park via the community of Ursine.

SR 322 heads northward through town as Main Street.

SR 322 then turns northward, passing briefly through the town of Ursine before meeting its terminus at Spring Valley State Park.

This designation was removed in favor of SR 322 in the 1976 renumbering of Nevada's state highways.

The entire route is in Lincoln County.