Those with nevus depigmentosus may be prone to sunburn due to the lack of pigment, and the patient should use good sun protection.

Initial assessment can be made based on the presence of depigmented patches, and confirmed with a skin biopsy.

[citation needed] Different therapeutic modalities have been attempted to repigment the lesions of nevus depigmentosus such as PUVA, excimer laser, and different grafting techniques.

[7] Successful repigmentation was reported in a single case with 14 sessions of excimer laser treatment.

These factors need to be considered while consulting and offering any treatment to the patient of nevus depigmentosus.